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Isochem is a French chemicals company specialized in custom synthesis. The company's products and services are primarily destined for the following market sectors: : * pharmaceuticals (APIs or active ingredients for medicinal products and intermediates), : * cosmetics : * specialty chemicals. The company operates from four production sites in France and also has: : * two industrial subsidiaries outside France: Framochem in Hungary and Wychem in the UK; : * a sales subsidiary in Germany. == History== * 1974 : Isochem created in Gennevilliers * 1977 : Pithiviers (ex. Agrifarm) site opened * 1979 : 1st U.S. Food and Drug Administration (FDA) audit and approval; export market development * 1990 : Isochem joins Groupe SNPE * 1991 : Isochem acquires the Vert-le-Petit site (ex IRCHA Fine Chemicals and Propeptide)〔 (Infogreffe Isochem ) 〕 * 2003 : acquisition of the Pont-de-Claix platform and the Hungarian subsidiary Framochem * 2010 : acquisition of Isochem by the German industrial holding company 〔 (), Isochem cherche des chemins pour grandir, Industrie Pharma, octobre, 2010.〕 * 2012 : acquisition of Wychem (UK) by Isochem 〔(), Isochem rachète la société britannique Wychem, Industrie Pharma, janvier, 2013.〕,〔(), Isochem renforce son offre en chimie fine et s'implante en Grande-Bretagne, Usine Nouvelle, juillet, 2013.〕 * 2014 : sale of Framochem subsidiary by Isochem Initially specialized in the extraction and hemisynthesis of natural substances such as quinine, Isochem has gradually expanded its expertise in the field of multi-step industrial production 〔Growing challenges of API process development in custom manufacturing, Chimica Oggi / Chemistry Today, 27, n°5, september-october, 2009.〕 encompassing a variety of operations including Grignard, Friedel-Crafts, Sandmeyer, Vilsmeier-Haack Reaction, deprotonation using butyllithium, reduction using metal hydrides and hydrogenation.〔Hydrogenation the key?, Specialty Chemicals Magazine, juin, 2009.〕 In the 1990s, synergies with groupe SNPE enabled Isochem to implement new technologies such as phosgenation,〔Phosgene Futures, Specialty Chemicals Magazine, November, 2011.〕 nitration and manufacture of amino-acid derivatives such as NCAs〔(), Controlled Ring Opening of ''N''-Sulfinyl- and ''N''-Silyl-''N''-Carboxyanhydrides (NCA), Synlett, 2009 (2), 279-283.〕,〔Amino-Acid ''N''-CarboxyAnhydrides: Industrial solutions for a growing demand, Specialty Chemicals Magazine, 28, n°5, june, 2008.〕 UNCAs and peptides.〔Peptide synthesis and Fine Chemistry merging for progress, PharmaChem, novembre-december, 2004〕,〔UNCAs - Focus on peptides & Amino-acids, Chimica Oggi / Chemistry Today, 23, n°3, june, 2005.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Isochem company」の詳細全文を読む スポンサード リンク
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